Protein Folding, Misfolding and Aggregation: Classical Themes and Novel Approaches

✍ Scribed by Victor Muñoz

• Publisher: Royal Society of Chemistry
• Year: 2008
• Tongue: English
• Leaves: 289
• Series: RSC Biomolecular Sciences
• Edition: 1
• Category: Library

✦ Synopsis

This unique book covers all the modern approaches and the many advances experienced in the field during the last 10 years. There is much emphasis on computational methods and studies of protein aggregation which have really flourished in the last decade. It includes chapters in the areas that have witnessed major developments and written by top experts including: computer simulations of folding, fast folding, single molecule spectroscopy, protein design, aggregation studies (both computational and experimental). Readers will obtain a unique perspective of the problems faced in the biophysical study of protein conformational behavior in aqueous solution and how these problems are being solved with a multidisciplinary approach that combines theory, experiment and computer simulations.

✦ Table of Contents

Front Cover
......Page 1
Protein Folding, Misfolding and Aggregation:
Classical Themes and Novel Approaches......Page 4
Copyright
Royal Society of Chemistry 2008......Page 5
Preface......Page 6
Contents......Page 10
CHAPTER 1
The a-Helix as the Simplest
Protein Model: Helix–Coil
Theory, Stability, and Design......Page 18
CHAPTER 2
Kinetics and Mechanisms
of a-Helix Formation......Page 45
CHAPTER 3
The Protein Folding Energy
Landscape: A Primer......Page 66
CHAPTER 4
Hydrogen Exchange
Experiments: Detection and
Characterization of Protein
Folding Intermediates......Page 87
CHAPTER 5
Statistical Differential Scanning
Calorimetry: Probing Protein
Folding–Unfolding Ensembles......Page 102
CHAPTER 6
Fast Protein Folding......Page 123
CHAPTER 7
Single Molecule Spectroscopy in
Protein Folding: From
Ensembles to Single Molecules......Page 156
CHAPTER 8
Computer Simulations
of Protein Folding......Page 178
CHAPTER 9
Protein Design: Tailoring
Sequence, Structure, and Folding
Properties......Page 205
CHAPTER 10
Protein Misfolding and
b-Amyloid Formation......Page 231
CHAPTER 11
Scenarios for Protein
Aggregation: Molecular
Dynamics Simulations and
Bioinformatics Analysis......Page 258
Subject Index......Page 283