Protein fold recognition by prediction-based threading
โ Scribed by Burkhard Rost; Reinhard Schneider; Chris Sander
- Book ID
- 115627993
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 302 KB
- Volume
- 270
- Category
- Article
- ISSN
- 0022-2836
No coin nor oath required. For personal study only.
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Analysis of our fold recognition results in the 3rd Critical Assessment in Structure Prediction (CASP3) experiment, using the programs THREADER 2 and GenTHREADER, shows an encouraging level of overall success. Of the 23 submitted predictions, 20 targets showed no clear sequence similarity to protein
Protein structure prediction is limited by the inaccuracy of the simplified energy functions necessary for efficient sorting over many conformations. It was recently suggested (Finkelstein, Phys Rev Lett 1998;80:4823-4825) that these errors can be reduced by energy averaging over a set of homologous
## Abstract In protein fold recognition, one assigns a probe amino acid sequence of unknown structure to one of a library of target 3D structures. Correct assignment depends on effective scoring of the probe sequence for its compatibility with each of the target structures. Here we show that, in ad