## Abstract The cellular surveillance systems guarantee proper removal of altered components from inside cells. Alterations of these systems in neurons have been proposed to be involved in the pathogenesis of different neurodegenerative disorders. In this review, we comment on the advances in our c
Protein degradation and protection against misfolded or damaged proteins
β Scribed by Goldberg, Alfred L.
- Book ID
- 109892645
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 195 KB
- Volume
- 426
- Category
- Article
- ISSN
- 0028-0836
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Investigations of genetic diseases such as cystic fibrosis, a-1-antitrypsin deficiency, phenylketonuria, mitochondrial acyl-CoA dehydrogenase deficiencies, and many others have shown that enhanced proteolytic degradation of mutant proteins is a common molecular pathological mechanism. Detailed studi
Heat-induced nuclear protein aggregation and subsequent disaggregation were measured in nonpreheated and preheated (thermotolerant) HeLa S3 cells. The effect of thermotolerance on the formation of and recovery from heat-induced nuclear protein aggregates was related to the cellular levels of hsp27,