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Protein degradation, aggregation, and misfolding

✍ Scribed by Ana Maria Cuervo; Esther S.P. Wong; Marta Martinez-Vicente

Book ID
102508952
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
135 KB
Volume
25
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

The cellular surveillance systems guarantee proper removal of altered components from inside cells. Alterations of these systems in neurons have been proposed to be involved in the pathogenesis of different neurodegenerative disorders. In this review, we comment on the advances in our current understanding of how changes in the intracellular proteolytic systems, the main components of the cellular quality control system, contribute to neurodegeneration, with special emphasis on Parkinson's disease. Β© 2010 Movement Disorder Society

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