Pharmacological and biochemical studies
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H. Kruse; I. Hoffmann; H. J. Gerhards; M. Leven; U. Schacht
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Article
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1977
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Springer
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English
β 571 KB
Three major metabolites (M1, M2, M3) of nomifensine (8-amino-1,2,3,4-tetrahydro-2-methyl-4-phenyl-isoquinoline) are formed by hydroxylation and methoxylation of the phenyl ring. They were compared with nomifensine 1. in various psychopharmacological tests in vivo, carried out in mice after oral or i