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Protein binding investigation by difference circular dichroism: Native and acetylated human serum albumins

✍ Scribed by Carlo Bertucci; Alessandro Viegi; Giorgio Ascoli; Piero Salvadori

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 500 KB
Volume: 7
Category: Article
ISSN: 0899-0042
DOI: 10.1002/chir.530070202

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✦ Synopsis

A modified albumin was prepared by selective reaction of Lys,, with acetyl salicylic acid. Protein binding investigation was camed out on native and modified proteins by difference circular dichroism (ACD). Acetylation of Lyslgg reduces sigdicantly the effects of the interaction between drugs in the stereoselective HSA bindmg at specific binding areas.

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