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Protein Aggregation in vitro and in vivo: A Quantitative Model of the Kinetic Competition between Folding and Aggregation

โœ Scribed by Kiefhaber, Thomas ;Rudolph, Rainer ;Kohler, Hans-Helmut ;Buchner, Johannes


Book ID
117993515
Publisher
Nature Publishing Group
Year
1991
Tongue
English
Weight
750 KB
Volume
9
Category
Article
ISSN
1087-0156

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Protein aggregation has been associated with a number of human diseases, and is a serious problem in the manufacture of recombinant proteins. Of particular interest to the biotechnology industry is deleterious aggregation that occurs during the refolding of proteins from inclusion bodies. As a compl