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Protective Effects of Carvedilol in the Myocardium

✍ Scribed by Giora Z Feuerstein MD; Antoine Bril PhD; Robert R Ruffolo Jr; PhD

Book ID: 113978954
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 81 KB
Volume: 80
Category: Article
ISSN: 0002-9149
DOI: 10.1016/s0002-9149(97)00847-3

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Carvedilol, a new beta-blocker with vasodilating properties due to alpha 1-blockade, was investigated in preparations of human ventricular myocardium. Carvedilol demonstrated a high affinity and is a slightly beta 1-selective competitive beta-blocking agent, with a KD for beta 1-receptors of approxi