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Protective effects of Aβ-derived tripeptide, Aβ32–34, on Aβ1–42-induced phosphatidylinositol 4-kinase inhibition and neurotoxicity

✍ Scribed by Zheng-Mei Xiong; Kaori Kitagawa; Yuji Nishiuchi; Terutoshi Kimura; Chiyoko Inagaki

Book ID: 116769579
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 657 KB
Volume: 419
Category: Article
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2007.04.022

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## Abstract Glutathione (GSH) is an important endogenous antioxidant found in millimolar concentrations in the brain. GSH levels have been shown to decrease with aging. Alzheimer's disease (AD) is a neurodegenerative disorder associated with aging and oxidative stress. Aβ(1–42) has been shown to in