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Involvement of PI3-K pathway and β-catenin signaling in curcumin protecting against Aβ1-42-induced neurotoxicity

✍ Scribed by Hoppe, Juliana Bender; Frozza, Rudimar; Meneghetti, André; Bernardi, Andressa; da Silva, Thaline; Gerhardt, Daniéli; Salbego, Christianne


Book ID
122641415
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
75 KB
Volume
7
Category
Article
ISSN
1552-5260

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## Abstract Amyloid‐β peptide (Aβ) has been implicated in the etiopathogenesis of Alzheimer's disease (AD). However, the molecular mechanisms underlying Aβ neurotoxicity remain to be elucidated. This study showed that Aβ treatment resulted in the increased phosphorylation (activation) of MLK3, MKK7