Protection of the carboxy group in the form of the 2-cyanoethyl ester in synthesis of peptides
โ Scribed by V. V. Kalashnikov; V. V. Samukov
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 291 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0009-3130
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๐ SIMILAR VOLUMES
j For glycosylations of N-acetylneuraminic acid based on the use of 2-chloro and 2-hromo derivatives, see e.g. ~41. \*) The analogous methyl ester has been described in [lo].
As part of our long range program for developing a synthesis,' we wish to report the preparation and uses Maq esters. Esters of the 2-oxymethyleneanthraquinone tional operations of peptide synthesis but are cleaved mild reducing agents. compatible set of new reagents for peptide of a new carboxyl pr
## Abstract 2โThiopyridone (2โmercaptopyridine, **1**) was found to be a very suitable reagent for removing the __N__^ฮฑ^โoโnitrophenylsulfenyl (NPSโ) group in both conventional and solidโsupport peptide synthesis. A 3โ to 5โmolar excess of the reagent together with an equivalent amount of glacial a
In this communication we introduce a promising masking agent --the vinyloxycarbonyl or VOC group --for the protection of amino functions in peptide chemistry. Amino acids are easily converted to their N-VOC derivatives (l\_) in dilute aqueous base using the known vinyl chloroformate' in dioxane as t