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Protection of primary amino as pyrrole in organometallic reagents

✍ Scribed by Anthony P. Davis; Thomas J. Egan

Book ID: 104214749
Publisher: Elsevier Science
Year: 1992
Tongue: French
Weight: 127 KB
Volume: 33
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)74737-x

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✦ Synopsis

Pyrrole 5 was converted into Grignard and organocuprate reagents. After addition of the latter to alkene 6, the pyrrole ring was converted to a primary amine by ozonolysis, reduction and hydrolysis.

In the course of our programme on the synthesis of "cholaphanes", macrocyclic host molecules derived from cholic acid (l),' we have required synthons of the general form 2 for use in the introduction of a spacer

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