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Protection of leukemic cells by deoxycytidine: in vitro measures of protection against cytosine arabinoside

โœ Scribed by Justin D Cohen; David J Strock; Elizabeth A LaGuardia; Zhi Mao; Joanne E Teik


Book ID
114119430
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
176 KB
Volume
22
Category
Article
ISSN
0145-2126

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Drug resistance is one of the major reasons for failure of chemotherapy of acute leukemia with cytosine arabinoside (AM-C). In order to overcome this problem we have investigated the interaction of ARA-C with 3-deazauridine (3-DU) against HL-60 myeloid leukemic cells. 3-DU is an interesting agent to