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Comparison of antineoplastic activity of cytosine arabinoside and 5-aza-2′-deoxycytidine against human leukemic cells of different phenotype

✍ Scribed by Richard L. Momparler; Nicole Onetto-Pothier; Louise F. Momparler


Book ID
113239196
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
544 KB
Volume
14
Category
Article
ISSN
0145-2126

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Drug resistance is one of the major reasons for failure of chemotherapy of acute leukemia with cytosine arabinoside (AM-C). In order to overcome this problem we have investigated the interaction of ARA-C with 3-deazauridine (3-DU) against HL-60 myeloid leukemic cells. 3-DU is an interesting agent to