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Protection of carboxamide functions by the trityl residue. Application to peptide synthesis

✍ Scribed by Peter Sieber; Bernhard Riniker

Publisher: Elsevier Science
Year: 1991
Tongue: French
Weight: 341 KB
Volume: 32
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)74872-6

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✦ Synopsis

Carboxamlde fun&Ions may be tntylated by an aad-catalyzed reaction wth tnphenylmethanol and acetic anhydnde m glaaal acetic acid The w-tntyl group of asparagme and glutamme 1s cleavable by TFA, but stable to strong rnmeral aads m aqueous solution, as well as to nucleophlles and bases In pepbde syntheses, It 1s Ideally sulted for combmatlon with slde-cham protectlons of the t butyl-type

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