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Electrochemical removal of the picolinoyl group under mild acidic conditions. Application to the protection of amines in peptide synthesis

✍ Scribed by Nicolas Auzeil; Gilles Dutruc-Rosset; Martine Largeron

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
300 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

The picolinoyl group can be used as a convenient protective group for amines in peptide chemistry. Deprotection is performed by electrochemical reduction under mild acidic conditions.

📜 SIMILAR VOLUMES

Aryldithioethyloxycarbonyl (Ardec): A Ne
Aryldithioethyloxycarbonyl (Ardec): A New Family of Amine Protecting Groups Removable under Mild Reducing Conditions and Their Applications to Peptide Synthesis
✍ Milaine Lapeyre; Jérôme Leprince; Marc Massonneau; Hassan Oulyadi; Pierre-Yves R 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 572 KB

## Abstract The development of phenyldithioethyloxycarbonyl (Phdec) and 2‐pyridyldithioethyloxycarbonyl (Pydec) protecting groups, which are thiol‐labile urethanes, is described. These new disulfide‐based protecting groups were introduced onto the ε‐amino group of L‐lysine; the resulting amino acid