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Protection during peptide synthesis: Some new directions

✍ Scribed by Geoffrey T. Young

Publisher
Wiley (John Wiley & Sons)
Year
1981
Tongue
English
Weight
251 KB
Volume
20
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

Methods available for the protection of the functional groups of amino acids during peptide synthesis are discussed, and attention is drawn to the advantages of side‐chain protection of the 4‐pyridylmethyl type, having increased acid stability and cleaved by mild reductive procedures in the presence of sulfur. The use of S‐diphenyl‐4‐pyridylmethyl‐cysteine and N^im^‐diphenyl‐4‐pyridylmethyl‐histidine is described.

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