Protection by zinc against acetaminophen induced hepatotoxicity in mice*1
โ Scribed by CHENGELIS, C
- Book ID
- 121279748
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 598 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0272-0590
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Recent observations suggest that products of nonparenchymal liver cells such as eicosanoids and cytokines might play a role in the expression of liver injury after administration of acetaminophen and other noxious agents. We therefore investigated the effect of a fish oil diet, which results in the
## Abstract A series of doubleโprodrugs of Lโcysteine, designed to release Lโcysteine in vivo and stimulate the biosynthesis of glutathione (GSH), were synthesized. To evaluate the hepatoprotective effectiveness of these doubleโprodrugs, male SwissโWebster mice were administered acetaminophen (ACP)