Protection against cisplatin nephrotoxicity by prochlorperazine
β Scribed by R. A. Kramer
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 504 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0344-5704
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Key words: nephrotoxicity; cisplatin; radical scavengers; methimazole; rat In adult rats 6 mg kg -1 body wt. cisplatin given i.p. was nephrotoxic. Four days of i.p. treatment with 40 mg kg -1 body wt. methimazole, which started 1 day before CP, prevented increases in blood urea nitrogen and in the r
Probenecid inhibits cisplatin (CP) secretion in humans and protects against CPinduced nephrotoxicity in rats. The authors conducted a Phase I trial of escalating doses of CP using probenecid as a chemoprotector. Fifty-four courses of CP at doses ranging from 100 to 160 mg/m\* were given by 24-hour i