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Protection against carbon tetrachloride-induced hepatotoxicity by protein A

✍ Scribed by K. P. Singh; A. K. Saxena; S. I. A. Zaidi; P. D. Dwivedi; S. P. Srivastava; P. K. Seth; P. K. Ray

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
369 KB
Volume
8
Category
Article
ISSN
0260-437X

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✦ Synopsis

Protection from carbon tetrachloride ( CCIJ-induced hepatotoxicity by protein A was assessed histologically in rats. Carbon tetrachloride exposure produced swollen, vacuolated and necrotic cells in the centrilobular region of the hepatocyte in rats. Animals given protein A prior to and during CCl, treatment showed a complete absence of hepatic lesions. Our study showed that protein A, a potent irnmunornodulator, has the potential to reduce liver injury caused by carbon tetrachloride, a known hepatotoxin in the rat.

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