Protection against carbon tetrachloride hepatotoxicity by pretreatment with indole-3-carbinol
โ Scribed by H.G. Shertzer; M.P. Niemi; F.A. Reitman; M.L. Berger; B.L. Myers; M.W. Tabor
- Book ID
- 113147386
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 702 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0014-4800
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Protection from carbon tetrachloride ( CCIJ-induced hepatotoxicity by protein A was assessed histologically in rats. Carbon tetrachloride exposure produced swollen, vacuolated and necrotic cells in the centrilobular region of the hepatocyte in rats. Animals given protein A prior to and during CCl, t
Bacterial endotoxin (lipopolysaccharide, LPS) is known to potentiate the toxicity of many hepatotoxicants. However, exposure to a sublethal dose of LPS renders animals tolerant to a lethal dose of LPS, and protects against the toxicity of some chemicals. This study was designed to examine the effect