Proteasome inhibition and Parkinson's disease modeling
✍ Scribed by Jordi Bové; Chun Zhou; Vernice Jackson-Lewis; Julie Taylor; Yaping Chu; Hardy J. Rideout; Du-Chu Wu; Jeffrey H. Kordower; Leonard Petrucelli; Serge Przedborski
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 937 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Increasing genetic, pathological, and experimental evidence suggest that neurodegeneration in both familial and sporadic forms of Parkinson's disease (PD) may be related to a defect in the capacity of the ubiquitin–proteasome system (UPS) to clear unwanted proteins, resulting in protein
Among heat shock proteins, mortalin has been linked to the pathogenesis of Parkinson's disease. In the present work a rat model of Parkinson's disease was used to analyze the expression of striatal proteins and, more specifically, mortalin expression. The possible involvement of mortalin in Parkinso
## Abstract Parkinson's disease (PD) is a heterogenous disease likely to be caused by more than one specific aetiological factor. In rare familial cases of PD with similar clinical features to the idiopathic form of the disease, the underlying genetic cause has been identified. These PD‐associated