The relationship between Fas-mediated apoptosis and Type 1 diabetes is currently under investigation. Fas/Fas ligand interaction could be involved both in the insulitis process and in beta-cell death. Nevertheless, different mechanisms appear to be involved in human Type 1 diabetes and in NOD mice.
Proteases in Fas-mediated apoptosis
✍ Scribed by Boris Zhivotovsky; David H. Burgess; Jörg Schlegel; M. Isabella Pörn; Daina Vanags; Sten Orrenius
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 156 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0730-2312
No coin nor oath required. For personal study only.
✦ Synopsis
Involvement of a unique family of cysteine proteases in the multistep apoptotic process has been documented. Cloning of several mammalian genes identifies some components of this cellular response. However, it is currently unclear which protease plays a role as a signal and/or effector of apoptosis. We summarize contributions to the data concerning proteases in Fas-mediated apoptosis.
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