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Fas and Fas ligand-mediated apoptosis and its role in autoimmune diabetes

✍ Scribed by Signore, Alberto ;Annovazzi, Alessio ;Gradini, Roberto ;Liddi, Roberto ;Ruberti, Giovina

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
229 KB
Volume
14
Category
Article
ISSN
0742-4221

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✦ Synopsis

The relationship between Fas-mediated apoptosis and Type 1 diabetes is currently under investigation. Fas/Fas ligand interaction could be involved both in the insulitis process and in beta-cell death. Nevertheless, different mechanisms appear to be involved in human Type 1 diabetes and in NOD mice. In the present work, we review recent evidence of the role of the Fas/Fas ligand system in human and NOD mouse diabetes, describing possible hypotheses for its involvement in the pathogenesis of the disease, with possible implications for therapy and islet transplantation.

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