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Protease-catalyzed enantioselective synthesis of optically active 14-dihydropyridines

✍ Scribed by Yoshihiko Hirose; Kinya Kariya; Ikuharu Sasaki; Yoshiaki Kurono; Kazuo Achiwa

Book ID
104215821
Publisher
Elsevier Science
Year
1993
Tongue
French
Weight
238 KB
Volume
34
Category
Article
ISSN
0040-4039

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✦ Synopsis

The fast enanfiosclecfive pm4tease-ca~yzed hydrelyses of 1,4-dihydropysklk~-3,5~_~ diesters were developed. The monoesters obtained had high optical purity and wege useful chiral tmildiNg MOCKS which could ~ lead to optically active Cablockers.

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We are grateful to the Fonds der Chemischen Industrie for financial support, and S.-M.L. thanks the Alexander von Humboldt Foundation for a postdoctoral fellowship. We also acknowledge Dr. C. Jaekel (BASF AG) for pointing out Refs. [5h] and [6].