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ChemInform Abstract: Optically Active Dihydropyridines via Lipase-Catalyzed Enantioselective Hydrolysis.

โœ Scribed by L. SALAZAR; C. J. SIH


Book ID
112030452
Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
27
Category
Article
ISSN
0931-7597

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Optically-active dihydropyridines via li
โœ Loreto Salazar; Charles J. Sih ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 205 KB

Several prochiral esters of 1,4-dihydropyridines were enantioselectively hydrolyzed by Pseudomonas lipases (AK, P-30, and K-10) and Candida cylindracea lipase (OF-360). The stereochemical preferences of the lipases P-30 and K-10 were found to be always 4-Pro R and that of OF-360 to be 4-Pro S. In co