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Protease-activated receptor-4: a novel mechanism of inflammatory pain modulation

โœ Scribed by S Asfaha; N Cenac; S Houle; C Altier; M D Papez; C Nguyen; M Steinhoff; K Chapman; G W Zamponi; N Vergnolle


Book ID
110009363
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
184 KB
Volume
150
Category
Article
ISSN
0007-1188

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โœ Luoling Xu; Masud H. Khandaker; Jana Barlic; Longsi Ran; Miren L. Borja; Joaquin ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 248 KB

In the present study, we explored the molecular mechanisms by which bacterial endotoxin (LPS) mediates the down-regulation of CCR2 receptors on human monocytes. We found that LPS induced a marked reduction in CCR2 cell surface protein levels which was blocked by pretreatment with the tyrosine kinase