Prostatic intraepithelial neoplasia (PIN): Current concepts

✍ Scribed by David G. Bostwick

• Book ID: 102879852
• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 890 KB
• Volume: 50
• Category: Article
• ISSN: 0730-2312
• DOI: 10.1002/jcb.240501205

✦ Synopsis

Prostatic intraepithelial neoplasia (PIN) represents the putative precancerous end of the morphologic continuum of cellular proliferations within prostatic ducts, ductules and acini. Two gradesof PIN are identified (low grade and high grade), and high grade PIN is considered to be a precursorto invasive carcinoma. The continuum which culminates in high grade PIN and early invasive cancer is characterized by basal cell layer disruption, basement membrane disruption, progressive loss of secretory differentiation markers, increasing nuclear and nucleolar abnormalities, increasing proliferative potential, and increasing variation in DNAcontent (aneuploidy). Clinical studies suggest that PIN predates carcinoma by ten years or more, with low grade PIN first emerging in men in the third decade of life. The clinical importance of recognizing PIN is based on its strong association with carcinoma; its identification in biopsy specimens of the prostate warrants further search for concurrent invasive carcinoma. o 1992 Wiley-Liss, Inc.