𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Prostate-Cancer-Targeted N-(2-Hydroxypropyl)methacrylamide Copolymer/Docetaxel Conjugates

✍ Scribed by Jihua Liu; Pavla Kopečková; Huaizhong Pan; Monika Sima; Patrick Bühler; Philipp Wolf; Ursula Elsässer-Beile; Jindřich Kopeček

Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
541 KB
Volume
12
Category
Article
ISSN
1616-5187

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Biodistribution, pharmacokinetics, and efficacy of prostate‐cancer‐targeted HPMA copolymer/DTX conjugates are evaluated in nude mice bearing prostate cancer C4‐2 xenografts. PSMA‐specific monoclonal antibodies 3F/11 are used as the targeting moiety. Control conjugates contain either non‐specific IgG or no IgG. The ratios of tumor accumulation to total background organs (heart, lung, kidney, liver, spleen and blood) accumulation increase substantially with time for the targeted conjugate, and the ratio at 48 h is 7‐fold higher than that at 6 h. Preliminary evaluation of the efficacy of the conjugates in vivo show tumor growth inhibition for all HPMA copolymer/DTX conjugates.magnified image

📜 SIMILAR VOLUMES

Synthesis and in vitro Characterization
Synthesis and in vitro Characterization of Semitelechelic Poly[N-(2-hydroxypropyl)methacrylamide]–Trastuzumab Conjugates Targeted to Breast Cancer
✍ Jun H. Lee; Gauri Sabnis; Anjan Nan 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 349 KB

## Abstract Trastuzumab (TRZ) is a humanized monoclonal antibody that targets the extracellular domain of the human epidermal growth factor receptor type 2 (Her2). Semitelechelic (ST) poly[__N__‐(2‐hydroxypropyl)methacrylamide]–TRZ conjugates are successfully synthesized and evaluated as a potentia

Release of Prostaglandin E1 from N-(2-Hy
Release of Prostaglandin E1 from N-(2-Hydroxypropyl)methacrylamide Copolymer Conjugates by Bone Cells
✍ Huaizhong Pan; Jihua Liu; Yuanyi Dong; Monika Sima; Pavla Kopečková; Maria Luisa 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 252 KB

## Abstract Bone‐targeting __N__‐(2‐hydroxypropyl)methacrylamide (HPMA) copolymer‐PGE~1~ conjugates, containing cathepsin K sensitive spacers, were incubated with induced osteoclasts and osteoblasts, their precursors, and control non‐skeletal cells. The release of PGE~1~ was monitored by an HPLC as

Methods of targeting N-(2-hydroxypropyl)
Methods of targeting N-(2-hydroxypropyl) methacrylamide copolymers to particular cell types
✍ Duncan, Ruth ;Lloyd, John B. ;Rejmanová, Pavla ;Kopeček, Jindřich 📂 Article 📅 1985 🏛 Wiley (John Wiley & Sons) ⚖ 404 KB

Soluble s y n t h e t i c polymers w i l l o n l y be u s e f u l a s drug c a r r i e r s , i f methods can be devised f o r t a r g e t i n g them t o s p e c i f i c c e l l types. Two approaches a r e c u r r e n t l y being i n v e s t i g a t e d . F i r s t l y , t h e i n c o r p o r a t i o

Conjugates of insulin with copolymers of
Conjugates of insulin with copolymers of N-(2-hydroxypropyl) methacrylamide: Effects on smooth muscle cell proliferation
✍ Chytry, Vladimir ;Letourneur, Didier ;Baudys, Miroslav ;Jozefonvicz, Jacqueline 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 802 KB

The hypothesis that an elevated plasma insulin level contributes to an increase in coronary heart disease has led to studies of the mitogenic effect of native insulin and its conjugates on smooth muscle cells (SMC). In this study, insulin was covalently attached to two water-soluble polymers contain