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Prostaglandins Up-Regulate Vascular Endothelial Growth Factor Production through Distinct Pathways in Differentiated U937 Cells

✍ Scribed by Hiromi Bamba; Shinichi Ota; Akira Kato; Chiaki Kawamoto; Kenji Fujiwara

Book ID
115586053
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
114 KB
Volume
273
Category
Article
ISSN
0006-291X

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Prostaglandin E 2 (PGE 2 ) has been shown to induce expression of vascular endothelial growth factor (VEGF) and other signaling molecules in several cancers. PGE 2 elicits its functions though four G-protein coupled membrane receptors (EP1-4). In this study, we investigated the role of EP receptors