Signal transducers and activators of transcription 3 up-regulates vascular endothelial growth factor production and tumor angiogenesis in head and neck squamous cell carcinoma
โ Scribed by Muneyuki Masuda; Hong-Ying Ruan; Aya Ito; Torahiko Nakashima; Satoshi Toh; Takahiro Wakasaki; Ryuji Yasumatsu; Yuichiro Kutratomi; Shizuo Komune; I. Bernard Weinstein
- Book ID
- 113832822
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 421 KB
- Volume
- 43
- Category
- Article
- ISSN
- 1368-8375
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## Abstract Numerous reports suggest that interleukinโ6 (ILโ6) promotes survival and proliferation of tumor cells through the phosphorylation of a cellโsignaling protein, signalโtransducerโandโactivatorโofโtranscriptionโ3 (STAT3). Constitutive activation of STAT3 in head and neck squamous cell carc