## Abstract Starting with the racemic aldehyde 4, prepared from the tris(trimethylsilyl) ether 3, the possibility was demonstrated of converting a trimethylsilylated primary hydroxy group with high selectivity into an aldehyde group in the presence of two trimethylsilylated secondary hydroxy groups
Prostaglandins and Prostaglandin Intermediates. XVII [1]. Synthesis of the Main Metabolite of the PGF2α Analogue Cloprostenol
✍ Scribed by Dr. Fritz Theil; Dr. Burkhard Costisella; Dr. Rainer Mahrwald; Prof. Dr. habil. Hans Gross; Prof. Dr. sc. nat. Hans Schick; Dr. sc. nat. Sigfrid Schwarz
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 374 KB
- Volume
- 328
- Category
- Article
- ISSN
- 1615-4150
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## Abstract The benzoylated Corey aldehyde 1a can be alkynylated with hept‐1‐ynyl‐triisopropoxytitanium in good chemical yield and high diastereoselectivity to the (R)‐alcohol 3c admixed with about 10% of the diastereomeric (S)‐alcohol 2c. Without removal of this admixture the (R)‐alcohol 3c was co
## Smmary: A facile 1,5-migration of a t-butyldimethylsilyl group and a new cleavage reaction of t-butyldimethylsilyl ether to alcohol in prostaglandin intermediates are described.