The growth factor-and phorbol ester-inducible prostaglandin H synthase (PGHS)-2 has been found to be constitutively overexpressed in epidermal tumors generated by the initiation-promotion protocol in murine skin, whereas the expression of PGHS-1 does not change under these conditions. In this paper
Prostaglandin H synthase-dependent genotoxicity of 2,4-Diaminotoluene
β Scribed by Y. H. Laurie Pan; G. Ramachandra Reddy; Dr. Gregory A. Reed
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 789 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0893-6692
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IL-4 also decreased expression of CD14, which is the LPS-LPS-binding protein (LBP) receptor. Down-regulation of this receptor correlated with decreased expression of PGHS-2 and release of PGEz. MATERIALS AND METHODS ## Reagents Recombinant human IL-1p and recombinant human IL-4 were purchased fr
TPA regulation of prostaglandin H synthase activity in primary and subcultured dog urothelial cells was investigated. Previous studies have demonstrated an early (0-2 hr) increase in PGE, synthesis mediated by TPA which is dependent upon release of endogenous arachidonic acid by a phospholipase-medi
Growth factors may play a role in the formation of prostaglandins (PG) by cerebral blood vessels during development or reaction to injury. In smooth muscle cultures isolated from murine cerebral microvessels PG production was induced with either serum or epidermal growth factor (EGF). Prostaglandin
## ABSTUCT We have used immunofluorescent techniques to examine the distribution of prostaglandin H synthase (PGHS) in ovine astrocyte-enriched secondary cultures and in mixed cortical cells in primary culture. A batteq of monoclonal and polyclonal antibodies specific for the constitutive (PGHS-1)