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Prostaglandin E2 regulates amyloid precursor protein expression via the EP2 receptor in cultured rat microglia

โœ Scribed by Amy M. Pooler; Anibal A. Arjona; Robert K. Lee; Richard J. Wurtman

Book ID
116766610
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
118 KB
Volume
362
Category
Article
ISSN
0304-3940

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We previously reported that cycloogenase (COX)-2-generated prostaglandin E2 (PGE2) had anti-apoptotic effects in UVB-exposed mouse skin that involved EP2-mediated signaling (Chun et al., Cancer Res. 2007; 67: 2015). Because survivin is a regulator of cell survival, the possible involvement of COX-2