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Prostaglandin E2 (PGE2) induces IL-6 in human orbital fibroblasts through a CREB-dependent mechanism

✍ Scribed by Nupur Raychaudhuri; Terry J. Smith

Book ID: 116399253
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 61 KB
Volume: 48
Category: Article
ISSN: 1043-4666
DOI: 10.1016/j.cyto.2009.07.488

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Objective. The cyclooxygenase (COX) metabolite, 15-deoxy-⌬ 12,14 -prostaglandin J 2 (15d-PGJ 2 ), has been reported to inhibit the expression of a number of genes involved in the pathogenesis of arthritis. However, its effects on COX-2 remain controversial. We undertook this study to investigate the