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15-Deoxy-Δ12,14-prostaglandin J2inhibits IL-1β-induced cyclooxygenase-2 expression in human synovial fibroblasts through a histone deacetylase-independent mechanism

✍ Scribed by K Farrajota, H Afif, J Martel-Pelletier, J-P Pelletier, X Li, S Cheng…

Book ID
120707230
Publisher
BioMed Central
Year
2004
Tongue
English
Weight
391 KB
Volume
6
Category
Article
ISSN
1478-6354

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Inhibition of interleukin-1β–induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Δ12,14-prostaglandin J2 through a histone deacetylase–independent mechanism
✍ Katherine Farrajota; Saranette Cheng; Johanne Martel-Pelletier; Hassan Afif; Jea 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 313 KB 👁 1 views

Objective. The cyclooxygenase (COX) metabolite, 15-deoxy-⌬ 12,14 -prostaglandin J 2 (15d-PGJ 2 ), has been reported to inhibit the expression of a number of genes involved in the pathogenesis of arthritis. However, its effects on COX-2 remain controversial. We undertook this study to investigate the