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15-Deoxy-Δ12,14-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-γ-independent mechanism

✍ Scribed by Burkhard Hinz; Kay Brune; Andreas Pahl


Book ID
117053425
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
129 KB
Volume
302
Category
Article
ISSN
0006-291X

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Objective. The cyclooxygenase (COX) metabolite, 15-deoxy-⌬ 12,14 -prostaglandin J 2 (15d-PGJ 2 ), has been reported to inhibit the expression of a number of genes involved in the pathogenesis of arthritis. However, its effects on COX-2 remain controversial. We undertook this study to investigate the