Prostaglandin D2 inhibits the proliferation of human neuroblastoma cells
β Scribed by Sakai, Toshiyuki; Yamaguchi, Nozomi; Kawai, Keiichi; Nishino, Hoyoku; Iwashima, Akio
- Book ID
- 122372488
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 401 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0304-3835
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## Abstract __MYCN__ and insulinβlike growth factor (IGF) system are important for the pathogenesis and development of neuroblastoma. We previously reported evidence of a direct linkage between MycN and the IGF system in KPβNβRT human neuroblastoma cells, where IGFβI induced both MycN expression at
Addition to the culture medium of prostaglandin (PG) D, resulted in the degeneration in a dose-and time-dependent manner of N18TG-2 cells cloned from mouse neuroblastoma. The EDso for PGD,-induced cytotoxicity was about 10 1(~. The degenerative changes were irreversible when the cells were exposed f