Friend erythroleukemia cells (FELC) served as a model system for cell differentiation because these cells can be triggered to differentiate by a variety of chemical agents. Treatment with the classical inducer of differentiation, hexamethylene bisacetamide (HMBA), stimulated superoxide dismutase (SO
โฆ LIBER โฆ
Prostaglandin A1 induces differentiation in friend erythroleukemia cells
โ Scribed by M. Gabriella Santoro; Arrigo Benedetto; Bernard M. Jaffe
- Book ID
- 119488555
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- English
- Weight
- 524 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0090-6980
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Dimethylsulfoxide (DMSO) converts almost all of the undifferentiated murine erythroleukemia cells (MEL or Friend cells, clone 745A) in a culture to differentiated cells that contain high levels of hemoglobin and that stop growing after a limited number of cell divisions. Contrary to other reports-th