𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Superoxide dismutase induces differentiation of friend erythroleukemia cells

✍ Scribed by Barbara S. Beckman; Arthur K. Balin; R. G. Allen

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
758 KB
Volume
139
Category
Article
ISSN
0021-9541

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✦ Synopsis

Friend erythroleukemia cells (FELC) served as a model system for cell differentiation because these cells can be triggered to differentiate by a variety of chemical agents. Treatment with the classical inducer of differentiation, hexamethylene bisacetamide (HMBA), stimulated superoxide dismutase (SOD) activity, which increased in parallel with HMBA-induced differentiation. Furthermore, FELC were shown to differentiate in response to the addition of liposomes containing SOD. Oxidative treatment with Iiposomes containing D-amino acid oxidase or xanthine oxidase, cumene peroxide, or potassium superoxide also induced differentiation, whereas antioxidants such as a-tocopherol, butylated hydroxytoluene, or p-carotene did not induce differentiation. Also, HMBA induction of differentiation was suppressed by treatment with antioxidants.

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