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Prospective evaluation of duodenal polyposis progression in familial adenomatous polyposis (FAP)patients, and genotype-phenotype correlation

✍ Scribed by Suarin, Jean-Christope; Ligneau, Blandine; Lepretre, Jean; Chavaillon, Annick; Napoleon, Bertrand; Ponchon, Thierry; Chaybialle, Jean-Alain; Hosp, E Herriot


Book ID
122532442
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
180 KB
Volume
118
Category
Article
ISSN
0016-5085

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Patients with Familial Adenomatous Polyposis (FAP) manifest numerous colorectal adenomas as well as benign and malignant extra-colonic lesions. Adenomatous polyposis coli (APC) gene mutations are the underlying genetic defect in FAP. We analyzed germline D N A of 81 unrelated FAP patients and evalua