Prophylaxis of Graft-Versus-Host Disease by Lentiviral-Mediated Expression of Herpes Simplex Virus-Thymidine Kinase and Ganciclovir Treatment
β Scribed by K. Xu; F. Zhu; B. Du; F. Gao; H. Cheng; X. Pan
- Book ID
- 116934696
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 500 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0041-1345
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Human non-small cell lung cancer (NSCLC) cells were transfected with recombinant prodrug herpes simplex virus type I thymidine kinase (HSV-tk) cDNA, and the selected clones underwent apoptosis in response to induction by antiviral ganciclovir (GCV). The efficiency of GCV-induced growth inhibition an