Male and female Wistar strain rats were given 0.05% N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in their drinking water for 6 weeks and then water without BBN for 18 weeks. Diethylstilbestrol and testosterone were implanted subcutaneously into both intact and gonadectomised animals before or after
โฆ LIBER โฆ
Prophylaxis of FANFT induced bladder tumours in rats by intravesical DNCB instillation
โ Scribed by Johnson, D.K. ;Pontes, J.E. ;Izbicki, R. ;Pierce, J.M.
- Publisher
- Springer
- Year
- 1980
- Tongue
- English
- Weight
- 183 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0300-5623
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The therapeutic effect of an aromatic retinoic acid analogue (Ro 10-9359) and mitomycin C (MMC) on rats with bladder tumours induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) was examined. Eight-week-old female Wistar rats were given 0.05% BBN in drinking water for 8 weeks. Therapy was started