𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of sex hormones on development of urinary bladder tumours in rats induced by N-butyl-N-(4-hydroxybutyl) nitrosamine

✍ Scribed by Okajima, E. ;Hiramatsu, T. ;Iriya, K. ;Ijuin, M. ;Matsushima, S. ;Yamada, K.

Publisher
Springer
Year
1975
Tongue
English
Weight
662 KB
Volume
3
Category
Article
ISSN
0300-5623

No coin nor oath required. For personal study only.

✦ Synopsis

Male and female Wistar strain rats were given 0.05% N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in their drinking water for 6 weeks and then water without BBN for 18 weeks. Diethylstilbestrol and testosterone were implanted subcutaneously into both intact and gonadectomised animals before or after treatment with BBN to evaluate their effects on the development of bladder tumours. Diethylstilboestrol reduced the incidence of bladder tumours significantly in male rats. The incidence was higher in female rats after spaying and administration of testosterone after BBN treatment, than in the intact female. These results suggest that diethylstilboestrol inhibits carcinogenesis of the urinary bladder induced by BBN and growth of bladder tumours induced by BBN, in male rats. On the other hand, testosterone seems to stimulate the growth of bladder tumours induced by BBN in female rats.

πŸ“œ SIMILAR VOLUMES

Effects of single chemotherapeutic agent
Effects of single chemotherapeutic agents on development of urinary bladder tumor induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in rats
✍ Babaya, K. ;Takahashi, S. ;Momose, H. ;Matsuki, H. ;Sasaki, K. ;Samma, S. ;Ozono πŸ“‚ Article πŸ“… 1987 πŸ› Springer 🌐 English βš– 537 KB

Chemotherapeutic agents were evaluated for effect on the development of urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in male Wistar strain rats. Seven hundred and two rats were given 0.05% BBN in drinking water for 8 weeks. After BBN treatment, the animals were divi

Absence of FGFR3 mutations in urinary bl
Absence of FGFR3 mutations in urinary bladder tumours of rats and mice treated with N-butyl-N-(-4-hydroxybutyl)nitrosamine
✍ Claire Dunois-LardΓ©; Olivier Levrel; Aude Brams; Jean Paul Thiery; FranΓ§ois Radv πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 225 KB

Frequent activating mutations of FGFR3 (fibroblast growth factor receptor 3) are found in human urothelial cell carcinomas, particularly in superficial papillary tumours (in 74%-84% of pTaG1-G2), but not in carcinomas in situ (CIS) and at a low rate in invasive tumours (in 16%-21% of pT1-4). In mice

Suppressive effect of 1,4-phenylene diis
Suppressive effect of 1,4-phenylene diisothiocyanate on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice
✍ Shigeyuki Sugie; Pham Quang Vinh; K.M. Wahidur Rahman; Jun Ushida; Hiroyuki Kohn πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 French βš– 131 KB

The modifying effects of dietary administration of 1,4-phenylene diisothiocyanate (DITC) on N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN)-induced urinary bladder carcinogenesis during the initiation and post-initiation phases were examined in male ICR mice. Five-week-old animals were divided into 5 g

Chemopreventive effects of diosmin and h
Chemopreventive effects of diosmin and hesperidin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary-bladder carcinogenesis in male ICR mice
✍ Muzheng Yang; Takuji Tanaka; Yoshinobu Hirose; Takashi Deguchi; Hideki Mori; Yuk πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 French βš– 107 KB πŸ‘ 1 views

The chemopreventive effects of 2 flavonoids (diosmin and hesperidin) on N-butyl-N-(4-hydroxybutyl)nitrosamine (OH-BBN)-induced urinary-bladder carcinogenesis were examined in male ICR mice. Animals were divided into 11 groups, and groups 1 to 7 were given OH-BBN (500 ppm) in the drinking water for 6