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Prophylactic and therapeutic benefits of a monoclonal antibody against the fusion protein of human metapneumovirus in a mouse model

✍ Scribed by Marie-Eve Hamelin; Constance Gagnon; Gregory A. Prince; Peter Kiener; JoAnn Suzich; Nancy Ulbrandt; Guy Boivin

Book ID: 113458421
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 990 KB
Volume: 88
Category: Article
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2010.07.001

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## Abstract When fused with the protein transduction domain (PTD) derived from the human immunodeficiency virus TAT protein, proteins can cross the blood–brain barrier and cell membrane and transfer into several tissues, including the brain, making protein therapy feasible for various neurological