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Properties of the Domain-II Voltage Sensor Determining the Function of Nav1.8 (SCN10A) Channels

✍ Scribed by Schirmeyer, Jana; Leipold, Enrico; Heinemann, Stefan H.


Book ID
122175795
Publisher
Biophysical Society
Year
2010
Tongue
English
Weight
35 KB
Volume
98
Category
Article
ISSN
0006-3495

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## Abstract The sodium channel gene __Scn8a__ encodes the channel Na~V~1.6, which is widely distributed in the central and peripheral nervous system. Na~V~1.6 is the major channel at the nodes of Ranvier in myelinated axons. Mutant alleles of mouse __Scn8a__ result in neurological disorders includi