✦ LIBER ✦

Properties of the blue-shifted emission of hematoporphyrin and related derivatives in aqueous solution

✍ Scribed by A. Andreoni; R. Cubeddu

Publisher: Elsevier Science
Year: 1983
Tongue: English
Weight: 417 KB
Volume: 100
Category: Article
ISSN: 0009-2614
DOI: 10.1016/0009-2614(83)87417-x

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✦ Synopsis

A blue-shift of the emission spectrum of hematoporphyrin and of its derivatives used in tumor phototherapy is shown to occur in water solutions. After 48 h incubation at 37°C. this emission becomes predominant, particularly in derivatives with a high degree of aggegdtion, and is characterized by a decay time of =7 _.6 ns. The appearance of this band. which is peaked at 580 nm, cm be interpreted on the basis of a binding mechanism of monomers to stable arggegates.

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