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Properties of pectin gel bead modified with pectin hydrolysate and chitosan

✍ Scribed by Yoshifumi Murata; Michiko Miyashita; Midori Kato; Kyouko Kofuji; Susumu Kawashima

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 80 KB
Volume: 24
Category: Article
ISSN: 0730-6679
DOI: 10.1002/adv.20029

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✦ Synopsis

Abstract

A calcium‐induced pectin gel bead (PB) containing pectin hydrolysate and/or chitosan (CS) was prepared, after which the relationship between erosion of the PB and drug release from the PB in artificial gastrointestinal juice was investigated. The PB gradually disintegrated in gastric fluid, and the rate of erosion of the PB was changed by modification of the gel matrix. The amount of calcium ion used to make the PB had little effect on drug release; however, adding CS to the PB markedly suppressed drug release in intestinal fluid. © 2005 Wiley Periodicals, Inc. Adv Polym Techn 24:46–50, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/adv.20029

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