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PROPERTIES OF HPV-POSITIVE AND HPV-NEGATIVE ANAL CARCINOMAS

✍ Scribed by WILLIAMS, G. R.; LU, Q. L.; B. LOVE, S.; TALBOT, I. C.; NORTHOVER, J. M. A.

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
548 KB
Volume
180
Category
Article
ISSN
0022-3417

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✦ Synopsis

Evidence of human papillomavirus (HPV) can he found in up to 85 per cent of anal carcinomas. In the vulva, a discrete subset of HPV-positive carcinomas which show koilocytic morphology and distinct clinical features has recently been identified (warty carcinoma). The morphological and prognostic features of HPV-positive and HPV-negative anal carcinomas were compared in this study of the tumour distribution of H P V DNA. Vulva1 and anal neoplasia are similar in many ways and we have also looked to see if their similarity extends to 'warty' morphology in relation to H P V status. Thirty-five resection specimens of anal carcinoma were examined with biotin-labelled probes for H P V 6, 11, 16, and 18 DNA, using a non-isotopic in situ hybridization (ISH) technique. No tumour was found to contain H P V 6,11, or 18. Twenty-four (72 per cent) showed positivity for H P V 16 DNA. Staining was homogenous and independent of local squamous, hasaloid, or ductal differentiation. The majority of tumours showed staining suggestive of episomal, non-productive HPV infection. HPV-positive tumours were more likely to occur in the anal canal than perianally and to show a mixed squamous and basaloid appearance. No difference between the two groups was found in patient age, presence of adjacent dysplasia, ductal differentiation, or prognosis. There was no correlation between condylomatous tumour morphology and HPV 16 DNA positivity; thus, a subset equivalent to vulval warty carcinoma could not be identified.

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