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Do HPV-negative cervical carcinomas exist??revisited

✍ Scribed by Herrington, C. Simon

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 127 KB
Volume: 189
Category: Article
ISSN: 0022-3417
DOI: 10.1002/(sici)1096-9896(199909)189:1<1::aid-path432>3.0.co;2-p

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✦ Synopsis

There has been considerable debate regarding the existence of HPV-negative cervical carcinoma. In this issue of the journal, using well-controlled methodology, Walboomers et al. demonstrate that HPV DNA is present in almost all invasive carcinomas in a large multinational study. This indicates that HPV-negative carcinoma is extremely uncommon, if it exists at all. It also implies that HPV testing, if optimally applied, is capable of a sensitivity approaching 100 per cent. This has significant implications for cervical screening.

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Based on improvements in HPV detection technology, it appears that an almost 100% HPV association is reached for cervical cancer, as demonstrated in an accompanying paper in this issue of the Journal. Factors which may explain the rare cases in which no HPV DNA is detectable include: improper sampli